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Can I take Atenolol and Sertraline together?

Drug interaction guide

Taking atenolol and sertraline together may cause your heart rate to slow down more than usual or lead to a drop in blood pressure when you stand up. This can make you feel dizzy, lightheaded, or faint.

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Why this happens

Both medications can affect your heart rate and blood pressure. Sertraline can also slightly interfere with how the liver processes certain beta-blockers, potentially increasing their effect, though this is less common with atenolol than other drugs in its class.

It is generally safe to take these together, but you should monitor how you feel. Be careful when standing up quickly from a sitting or lying position. If you feel very dizzy, experience a very slow pulse, or feel like you might faint, contact your GP.

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Asthma or COPD

Atenolol can cause severe breathing difficulties or trigger a life-threatening asthma attack, even if your breathing problems are mild.

Low sodium levels (hyponatremia)

Sertraline can cause a dangerous drop in blood sodium levels, especially in older adults. Seek medical help if you experience sudden confusion, headache, or weakness.

Stopping treatment suddenly

Never stop taking atenolol abruptly. Doing so can cause a rapid heart rate, severe chest pain, or a heart attack. Your dose must be reduced gradually by a doctor.

Alcohol

It is recommended to avoid drinking alcohol while taking sertraline. Alcohol can increase the sedative effects of the medication, making you feel more drowsy or dizzy, and may worsen the symptoms of depression or anxiety.

Caffeine (Coffee, Tea, Energy Drinks)

Caffeine can increase your heart rate and blood pressure, which may counteract the intended effects of atenolol. While moderate intake is usually fine, avoid excessive amounts if you find it makes your heart race or increases your blood pressure.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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