Can I take Atorvastatin and Candesartan together?

Why this happens

Atorvastatin and candesartan are processed by different pathways in the body. Atorvastatin is primarily broken down by a liver enzyme called CYP3A4, while candesartan is not significantly processed by this system. They do not interfere with each other's absorption or excretion.

You can safely take these medicines together as prescribed by your doctor. It is usually best to take them at the same time each day to help you remember. Always inform your doctor if you experience unusual muscle pain or weakness, which is a general side effect of statins, but not caused by taking it with candesartan.

Pregnancy

You must not take candesartan if you are pregnant or planning to become pregnant, as it can cause serious harm or death to an unborn baby. Use effective contraception while taking it.

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can harm the developing baby. Use effective contraception while taking it.

Muscle disorders (Rhabdomyolysis) - atorvastatin

You must report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. In rare cases, this can lead to serious kidney damage.

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This can increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres daily), though it is safest to avoid it altogether while taking this medicine.

Alcohol

While there is no direct interaction, drinking large amounts of alcohol can increase the risk of liver problems with atorvastatin. For candesartan, alcohol can increase the blood-pressure-lowering effect, which may make you feel dizzy or lightheaded. It is best to keep your alcohol intake within the recommended low-risk guidelines.

Salt substitutes (Potassium-based)

Candesartan can increase the levels of potassium in your blood. Many 'low-sodium' salt substitutes contain potassium chloride. Using these while taking candesartan can lead to dangerously high potassium levels (hyperkalaemia). Check with your pharmacist before using salt substitutes.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.