Can I take Atorvastatin and Flecainide together?

Why this happens

Atorvastatin and flecainide are processed by different pathways in the liver. Atorvastatin is primarily broken down by an enzyme called CYP3A4, while flecainide is handled by CYP2D6. Because they use different 'routes', they do not interfere with each other's levels in the blood.

You can continue taking both medications as prescribed by your doctor. However, always inform your healthcare provider if you experience unusual muscle pain (a potential side effect of statins) or changes in your heart rhythm, as these medications are treating your heart health and cholesterol levels.

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Grapefruit juice and caffeine

Avoid drinking large amounts of grapefruit juice as it can increase the levels of flecainide in your blood. You should also limit caffeine intake, as it can interfere with how the medicine controls your heart rhythm.

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

Dairy products (Milk)

In infants and children, milk can reduce the absorption of flecainide. While this is less common in adults, significant changes in dairy intake should be avoided.

Caffeine

Flecainide is used to treat heart rhythm problems. Caffeine (found in coffee, tea, and energy drinks) can stimulate the heart and may interfere with the effectiveness of the medicine or worsen your condition.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.