Can I take Atorvastatin and Lixiana together?

Why this happens

Atorvastatin is processed by a specific liver enzyme (CYP3A4), while Lixiana is mainly cleared by the kidneys and a transport protein (P-gp). Because they use different pathways, they do not interfere with how the body absorbs or breaks down the other. There is a very rare risk that statins can cause muscle breakdown, which can affect kidney function; if kidneys are affected, Lixiana levels could potentially rise, though this is extremely unlikely.

You can safely take these two medicines together as prescribed. You should monitor for any unusual bruising or bleeding (such as nosebleeds or bleeding gums). If you experience unexplained muscle pain, tenderness, or weakness, contact your doctor, as this is a known side effect of statins that requires monitoring.

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Bleeding risk

Lixiana significantly increases your risk of bleeding. You must seek urgent medical attention if you have a serious fall, a head injury, or experience signs of internal bleeding such as black tarry stools or coughing up blood.

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While there is no direct interaction between these medicines and alcohol, drinking large amounts of alcohol can increase the risk of liver problems with atorvastatin and increase the risk of stomach bleeding while taking Lixiana. It is recommended to stay within the low-risk weekly limits (14 units per week).

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.