Can I take Atorvastatin and Sertraline together?

Why this happens

Both medications are processed by the same enzymes in the liver (specifically CYP3A4). Because they are 'competing' for the same processing pathway, the body may break down atorvastatin more slowly than usual.

You can usually take these together, but you should be vigilant. Tell your doctor if you experience any unexplained muscle pain, tenderness, or weakness, especially if you also feel generally unwell or have a fever. Your doctor may monitor your liver function or muscle enzymes (CK levels) via blood tests.

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Bleeding risk

Sertraline increases your risk of bleeding. Seek medical advice before taking anti-inflammatory painkillers like ibuprofen or aspirin, as the combination can cause serious stomach bleeding.

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.