Can I take Atorvastatin and Shiitake together?

Why this happens

Shiitake mushrooms naturally contain a substance called eritadenine, which helps lower cholesterol. They also contain small amounts of naturally occurring statin-like compounds (similar to lovastatin). When taken with atorvastatin, these effects can add together (an additive effect), potentially increasing the level of statin activity in your body beyond what was intended by your prescription.

If you eat shiitake mushrooms occasionally as part of a normal diet, the risk is very low. However, you should avoid taking concentrated shiitake supplements or large medicinal amounts without speaking to your doctor first. If you experience any unexplained muscle pain, tenderness, or weakness while taking these together, contact your GP immediately.

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Blood clotting disorders or surgery

Shiitake supplements can thin the blood and increase the risk of bleeding. You must stop taking them at least two weeks before any scheduled surgery.

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.