Can I take Black cohosh and Vitamin B12 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There are no known interactions between black cohosh and vitamin B12. It is generally considered safe to take these two supplements together.
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Why this happens
Black cohosh and vitamin B12 are processed by the body through different pathways. Black cohosh is primarily broken down by the liver, while vitamin B12 is absorbed in the small intestine and does not interfere with the liver enzymes that process black cohosh. They do not have overlapping effects on the body's systems.
What you should do
Back to contentsYou can continue to take both supplements as directed. However, always inform your doctor or pharmacist about all the supplements you are taking, especially if you have a history of liver problems, as black cohosh has been rarely linked to liver issues.
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Important precautions
Back to contentsPregnancy
Do not use black cohosh during pregnancy. It may stimulate uterine contractions, potentially increasing the risk of miscarriage or premature labour.
Liver disease
Black cohosh has been linked to rare but serious cases of liver failure. You must stop taking it and see a doctor immediately if you develop yellowing of the skin or eyes, dark urine, or severe stomach pain.
Hormone-sensitive conditions (e.g. breast cancer)
Because black cohosh may act like the hormone oestrogen, you should not use it if you have a history of breast cancer, uterine cancer, or endometriosis without specialist medical supervision.
Food and drink warnings
Back to contentsAlcohol
Black cohosh has been linked to rare but serious cases of liver damage. Because alcohol also puts strain on the liver, it is advisable to limit or avoid alcohol consumption while taking this supplement to reduce the risk of liver toxicity.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Black garlic and Vitamin B complex together?
There are no known harmful interactions between black garlic and Vitamin B complex supplements. In fact, black garlic is naturally rich in several B vitamins, and taking them together is generally considered safe.
Treatment and medication
Can I take Black garlic and Evening primrose oil together?
Taking black garlic and evening primrose oil together may increase your risk of bruising or bleeding. This is because both supplements can thin the blood and slow down the time it takes for a clot to form.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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