Can I take Dextromethorphan cough medicines and Sertraline together?

Why this happens

Sertraline is an SSRI antidepressant that increases serotonin levels. Dextromethorphan cough medicines also slightly increases serotonin. When combined, they can raise serotonin to unsafe levels. Furthermore, both medicines can have a calming effect on the central nervous system, leading to increased sleepiness.

You should speak to your doctor or pharmacist before taking these together. They may suggest a different type of cough medicine that does not contain dextromethorphan (such as a simple linctus or a medicine containing only guaifenesin). If you are already taking both and feel very unwell, confused, or have a high fever, seek medical help immediately.

Bleeding disorders or use of blood thinners

Sertraline can increase your risk of serious bleeding, especially if you are also taking aspirin, ibuprofen, or blood-thinning medications like warfarin.

Bipolar disorder or history of mania

Sertraline can trigger a manic episode (extreme high mood and overactivity) in people with undiagnosed bipolar disorder.

Serotonin Syndrome risk

Check with a pharmacist before using certain cough suppressants (like dextromethorphan) with sertraline, as the combination can cause a life-threatening reaction called serotonin syndrome.

Alcohol

You should avoid drinking alcohol while taking these medicines. Both sertraline and dextromethorphan can cause drowsiness and dizziness; alcohol will significantly increase these effects, making you feel more sleepy and less alert.

Grapefruit juice

Avoid consuming large amounts of grapefruit juice. Grapefruit can increase the levels of sertraline in your blood, which may increase the risk of side effects.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.