Skip to main content

Can I take Ibuprofen lysine and Paracetamol together?

Drug interaction guide

Originally published 25 Jan 2026

Meets Patient’s editorial guidelines

It is safe to take ibuprofen lysine and paracetamol together. These two medicines work in different ways to relieve pain and reduce fever. Taking them together can often provide better pain relief than taking either one alone.

In this article:

You can take ibuprofen lysine and paracetamol together as they belong to different classes of painkillers and do not interfere with how the body absorbs or processes each other.

Paracetamol works mainly in the central nervous system to block pain signals, while ibuprofen (an NSAID) reduces inflammation and pain at the site of the injury.

How to take ibuprofen lysine and paracetamol

  • You can take these medicines at the same time or stagger them.

  • Always follow the dosage instructions on the packaging for each product.

  • Ensure you do not take more than the maximum daily dose for either medicine.

  • If you are using a 'combination' product that already contains both, do not take extra paracetamol or ibuprofen on top of it.

Using other medicines

Back to contents

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Patient picks for Drug interactions

Can I take Black cohosh and St John's wort together?

Treatment and medication

Can I take Black cohosh and St John's wort together?

Taking black cohosh and St John's wort together may increase the risk of liver irritation or damage. While both are often used together for menopause symptoms, there have been rare reports of liver problems associated with these supplements. Additionally, St John's wort can change how the body processes other substances, which might alter the levels of black cohosh in your system.

Can I take Calcium and Ezetimibe together?

Treatment and medication

Can I take Calcium and Ezetimibe together?

There is no known interaction between calcium supplements and ezetimibe. Taking these two together is generally considered safe and should not affect how well your cholesterol medication works.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.