Can I take Lanzoprole and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking lansoprazole and sertraline together can increase the amount of sertraline in your bloodstream. This may increase the risk of side effects such as feeling sick, diarrhoea, tremors, or feeling restless. In rare cases, it could lead to a serious condition called serotonin syndrome or affect your heart rhythm.
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Why this happens
Lansoprazole can slow down the liver enzymes (specifically CYP2C19) that are responsible for breaking down sertraline. Because the sertraline is broken down more slowly, it builds up in your body.
What you should do
Back to contentsYou can take these medicines together, but you should be aware of increased side effects. If you notice any unusual symptoms like extreme agitation, a very fast heartbeat, or muscle stiffness, contact your doctor. Your doctor may choose to adjust your sertraline dose if you need to take lansoprazole long-term.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Can I take Cannabis and Sertraline together?
Combining cannabis with sertraline can increase the risk of side effects such as extreme drowsiness, dizziness, and confusion. In rare cases, it may lead to a serious condition called serotonin syndrome, which causes symptoms like a racing heart, sweating, tremors, and agitation. Additionally, cannabis can sometimes worsen the anxiety or depression that sertraline is being used to treat.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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