Can I take Magnesium and Oestrogel pump-pack /actuation together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known direct interaction between magnesium supplements and Oestrogel (estradiol). Taking these two together is generally considered safe and may even be beneficial for some women during menopause.
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Why this happens
Magnesium is a mineral absorbed through the digestive system, while Oestrogel is a hormone absorbed through the skin (transdermally). Because they use different pathways and do not interfere with each other's metabolism in the liver or action at hormone receptors, they do not clash.
What you should do
Back to contentsYou can continue to use both as prescribed. It is often recommended to take magnesium in the evening as it can help with relaxation and sleep, while Oestrogel should be applied at the same time each day to clean, dry skin.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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