Can I take Omeprazole and Vitamin b12 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking omeprazole for a long time can make it harder for your body to absorb vitamin B12 from the food you eat. Over several years, this could lead to a vitamin B12 deficiency.
In this article:
Video picks for Drug interactions
Why this happens
Vitamin B12 is naturally bound to proteins in food. To release the vitamin so your body can use it, you need stomach acid. Omeprazole works by reducing the amount of acid your stomach produces. With less acid available, the B12 stays 'locked' in the food and passes through your system without being fully absorbed.
What you should do
Back to contentsIf you take omeprazole for more than 2 to 3 years, ask your doctor to check your vitamin B12 levels with a blood test. You should also watch for signs of low B12, such as feeling very tired, having a sore tongue, or feeling 'pins and needles'. If you need a supplement, high-dose oral tablets or B12 injections usually work well because they don't rely as much on stomach acid for absorption.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Black cohosh and St John's wort together?
Taking black cohosh and St John's wort together may increase the risk of liver irritation or damage. While both are often used together for menopause symptoms, there have been rare reports of liver problems associated with these supplements. Additionally, St John's wort can change how the body processes other substances, which might alter the levels of black cohosh in your system.

Treatment and medication
Can I take Black garlic and Evening primrose oil together?
Taking black garlic and evening primrose oil together may increase your risk of bruising or bleeding. This is because both supplements can thin the blood and slow down the time it takes for a clot to form.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.