Can I take Paracetamol adult and Sentraline together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There is no known direct interaction between paracetamol and sertraline. It is generally considered safe to take these two medicines together at the recommended doses.
In this article:
Video picks for Drug interactions
Why this happens
Paracetamol and sertraline are processed by different pathways in the liver and do not interfere with how the other is absorbed, broken down, or removed from the body. They also work on different systems in the body and do not have overlapping side effects.
What you should do
Back to contentsYou can take paracetamol while taking sertraline. Always follow the dosage instructions on the paracetamol packaging and do not exceed 4 grams (eight 500mg tablets) in a 24-hour period. If you find you need to take paracetamol every day for more than a few days, you should speak to your doctor or pharmacist.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Cannabis and Paracetamol together?
There are no known significant interactions between cannabis and paracetamol. It is generally considered safe to use them together at recommended doses.
Treatment and medication
Can I take Cannabis and Clozapine together?
Using cannabis while taking clozapine can significantly change the levels of the medicine in your blood. It can also increase the risk of serious side effects like extreme drowsiness, confusion, and heart problems. If you stop or start smoking cannabis suddenly, your clozapine levels could become dangerously high or too low, potentially leading to a relapse of your symptoms or severe toxicity.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.