Can I take Paracetamol and Shortec together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Shortec is a brand name for oxycodone. Many versions of oxycodone are sold as 'combination' products that already contain paracetamol (such as Percocet). If you take Shortec alongside paracetamol, the main risk is accidentally taking too much paracetamol. Taking more than the recommended dose of paracetamol can cause serious, life-threatening liver damage. Additionally, both drugs can cause drowsiness, though this effect is mainly driven by the Shortec.
In this article:
Video picks for Drug interactions
Why this happens
There is no direct 'clash' between how these two drugs work; in fact, they are often prescribed together because they kill pain in different ways. However, because paracetamol is hidden in many different cold, flu, and pain medicines, it is very easy to exceed the safe daily limit (4 grams or eight 500mg tablets in 24 hours) when using multiple products.
What you should do
Back to contentsIt is generally safe to take these together as long as you check your labels carefully. Ensure your Shortec capsules do not already contain paracetamol. Do not exceed 4000mg (4 grams) of paracetamol in any 24-hour period. If you feel excessively sleepy, dizzy, or have trouble breathing, seek medical help immediately. Always tell your pharmacist if you are buying over-the-counter paracetamol while being prescribed Shortec.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Calcium and Ezetimibe together?
There is no known interaction between calcium supplements and ezetimibe. Taking these two together is generally considered safe and should not affect how well your cholesterol medication works.

Treatment and medication
Can I take Calcium and Esomeprazole together?
Taking esomeprazole for a long time may reduce how much calcium your body absorbs from your diet or from certain supplements. This can lead to weaker bones and an increased risk of fractures, particularly in the hip, wrist, or spine, if used at high doses for over a year.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.