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Can I take Atorvastatin and Joint assurance together?

Drug interaction guide

Joint Assurance is a supplement that typically contains glucosamine and chondroitin. There is no evidence that these ingredients interfere with how atorvastatin works or how it is processed by your body. However, some people taking statins like atorvastatin report muscle aches, and very rarely, glucosamine might also cause mild muscle or joint discomfort in some individuals.

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Why this happens

There are no known pharmacokinetic interactions (how the body processes the drug) or pharmacodynamic interactions (how the drug affects the body) between atorvastatin and the common ingredients in Joint Assurance (glucosamine, chondroitin, or MSM).

It is generally safe to take these together. However, if you experience any new or unusual muscle pain, tenderness, or weakness while taking this combination, you should mention it to your doctor or pharmacist.

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Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Shellfish allergy

Many joint supplements are derived from shellfish. Do not take Joint Assurance if you have a shellfish allergy, as it may cause a severe allergic reaction.

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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