Can I take Naproxen and Tramadol together?

You can take naproxen and tramadol together if both have been prescribed by your doctor, but use the lowest dose for the shortest time, as taking them together can increase the risk of serious side effects, especially to your stomach and kidneys.

If you have a history of epilepsy, kidney problems, or stomach ulcers, talk to your pharmacist or doctor before combining them.

Always take them with food to protect your stomach.

Why this happens

Naproxen is an anti-inflammatory (NSAID) and tramadol is an opioid-like painkiller. Both can irritate the stomach lining, increasing the risk of ulcers or bleeding.

Both drugs also affect how the kidneys filter blood. Additionally, tramadol can lower the 'seizure threshold' (making a fit more likely), and while naproxen doesn't directly cause this, the combination of pain and multiple medications can increase overall physical stress.

You may be experiencing an interaction between naproxen and tramadol if you have:

• Severe stomach pain.

• Black or bloody poo (stools).

• Swelling in the legs.

• Severe drowsiness or confusion.

• Difficulty breathing.

• Are vomiting blood.

• Are peeing (urinating) less.

Seek medical attention urgently (ring 999 or go to A&E) if these symptoms occur.

• Only take both if prescribed or recommended by your doctor.

• Use the lowest effective dose for the shortest possible time.

• Take naproxen with food to reduce stomach irritation.

• Avoid alcohol, as it can increase drowsiness and stomach bleeding risk.

• Do not take other anti-inflammatory painkillers (such as ibuprofen) at the same time unless advised.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.