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Can I take 150 and Warfarin together?

Drug interaction guide

Taking aspirin (75mg to 150mg) with warfarin significantly increases your risk of serious bleeding, including internal bleeding and haemorrhagic stroke.

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Why this happens

Both medicines work to prevent blood clots but in different ways. Warfarin interferes with clotting factors in the blood, while aspirin stops platelets (blood cells) from sticking together. When used together, they 'double up' the blood-thinning effect. Additionally, aspirin can irritate the lining of the stomach, making it more likely to bleed, especially when warfarin is also present.

You should only take this combination if it has been specifically prescribed by a specialist (such as a cardiologist). Do not take 'over-the-counter' aspirin if you are on warfarin. If you are prescribed both, you must attend all blood test appointments (INR tests) and watch closely for signs of bleeding, such as unexplained bruising, blood in your urine or stools (which may look black and tarry), or nosebleeds that do not stop. Seek urgent medical help if you have a serious fall or hit your head.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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