Can I take 1mg and Pregabalin together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Taking alprazolam and pregabalin together can make you feel extremely sleepy, dizzy, and confused. It can also cause serious breathing problems, extreme clumsiness, and may lead to an accidental overdose or loss of consciousness.
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Why this happens
Both medicines are 'central nervous system depressants'. This means they both slow down the brain and the body's messages. When used together, their effects add up, making the sedative and breathing-slowing effects much stronger than when taken alone.
What you should do
Back to contentsYou should only take these two medicines together if they have been specifically prescribed by the same doctor who is aware of both prescriptions. Do not drive, operate machinery, or drink any alcohol while taking this combination. If you feel unusually sleepy or have any difficulty breathing, seek medical help immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published

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