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Can I take 1mg and Pregabalin together?

Drug interaction guide

Taking alprazolam and pregabalin together can make you feel extremely sleepy, dizzy, and confused. It can also cause serious breathing problems, extreme clumsiness, and may lead to an accidental overdose or loss of consciousness.

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Why this happens

Both medicines are 'central nervous system depressants'. This means they both slow down the brain and the body's messages. When used together, their effects add up, making the sedative and breathing-slowing effects much stronger than when taken alone.

You should only take these two medicines together if they have been specifically prescribed by the same doctor who is aware of both prescriptions. Do not drive, operate machinery, or drink any alcohol while taking this combination. If you feel unusually sleepy or have any difficulty breathing, seek medical help immediately.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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