Can I take 25 and Alcohol together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Combining alcohol with amitriptyline can cause extreme drowsiness, dizziness, and blurred vision. It significantly increases the risk of accidents and can lead to dangerous breathing problems or loss of consciousness.
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Why this happens
Both amitriptyline and alcohol are 'central nervous system depressants'. This means they both slow down brain activity. When taken together, they 'double up' on this effect, making the impact much stronger than either would be on its own.
What you should do
Back to contentsIt is best to avoid alcohol completely while taking amitriptyline, especially when you first start the medication or if your dose is increased. If you do choose to drink, keep it to a very small amount, but be aware that even one drink could make you feel very impaired. Never drive or operate machinery if you have combined these two.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published

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