Can I take Adizem and Amitriptyline together?

Why this happens

Adizem (diltiazem) slows down the liver enzymes (specifically CYP3D6 and CYP3A4) that your body uses to break down amitriptyline. This causes the amitriptyline to build up in your system. Additionally, both drugs have a 'calming' effect on the heart's electrical system, which can have an additive effect on your heart rate and rhythm.

You should speak to your doctor before taking these two medicines together. If they are prescribed together, your doctor may want to start you on a lower dose of amitriptyline or monitor your heart with an ECG (heart trace). Seek medical help immediately if you feel dizzy, faint, or notice a very slow or fluttering heartbeat.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.