Can I take Amitriptoline and Aspirin together?

Why this happens

Amitriptyline belongs to a group of medicines that can affect how your blood platelets work. When combined with aspirin (which also thins the blood), the risk of bruising or internal bleeding is higher. Additionally, both drugs can be tough on the stomach lining.

Use this combination with caution. If you are taking aspirin daily for heart protection, do not stop taking it, but inform your doctor you are also taking amitriptyline. Seek medical advice immediately if you notice signs of bleeding, such as dark 'tarry' stools, coughing up blood, or unusual bruising.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.