Can I take Amitriptyline and Metformin together?

Why this happens

Amitriptyline can affect how your body handles glucose (sugar) and may interfere with the way insulin works. It can also affect the 'warning signs' of low blood sugar, such as a fast heartbeat. There is no major evidence that these drugs change how each other are absorbed or cleared by the liver or kidneys.

It is generally safe to take these together, but you should monitor your blood sugar levels more closely when starting amitriptyline or changing your dose. Be aware of how you feel and report any unusual thirst, frequent urination, or signs of low blood sugar (like sweating or shaking) to your doctor. Ensure you attend your regular diabetes check-ups.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.