Can I take Amitriptyline and Propranolol together?

Why this happens

Both medicines can lower blood pressure and slow the heart rate. Additionally, propranolol may slow down the rate at which your liver breaks down amitriptyline, leading to higher levels of the antidepressant in your bloodstream. Both drugs also have a calming effect on the central nervous system, which increases sleepiness.

You can usually take these together, but your doctor should monitor you closely. Take care when standing up from a sitting or lying position to avoid dizziness. If you feel unusually sleepy, dizzy, or notice a fluttering in your chest, contact your doctor. Do not stop taking either medication without medical advice.

Asthma or COPD

You must not take this medicine if you have asthma or a history of wheezing. It can cause a severe, potentially life-threatening narrowing of your airways.

Suicidal thoughts

This medicine can increase thoughts of self-harm or suicide, particularly in the first few weeks of treatment. Seek urgent medical help if your mood changes or you feel distressed.

Diabetes

This medicine can hide the warning signs of low blood sugar (hypoglycaemia), such as a fast heartbeat or tremors. You must monitor your blood sugar more closely.

Alcohol

You should avoid or strictly limit alcohol while taking these medicines. Both amitriptyline and propranolol can cause drowsiness and dizziness; alcohol significantly increases these effects, which can impair your coordination and reaction times.

Caffeine (Coffee, tea, energy drinks)

Caffeine can counteract the effects of propranolol. Propranolol is often prescribed to lower heart rate and blood pressure, while caffeine is a stimulant that increases them. High intake of caffeine may make your medicine less effective.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.