Can I take Amlodipine and Pregabalin together?

Why this happens

This is a 'pharmacodynamic' interaction. Amlodipine works by relaxing blood vessels, which can sometimes cause fluid to leak into the tissues (swelling). Pregabalin can also cause fluid retention and affects the central nervous system, leading to drowsiness. When combined, these effects can add together.

It is generally safe to take these together, but you should be aware of increased tiredness or dizziness, especially when you first start the combination or change your dose. Be careful when driving or using machinery until you know how the drugs affect you. If you notice significant swelling in your legs or rapid weight gain, contact your GP.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.