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Can I take Apixaban and Bisodol indigestion relief together?

Drug interaction guide

Taking these two medicines together can increase your risk of serious bleeding, including internal bleeding or stomach ulcers. Bisodol contains aspirin, which thins the blood, and apixaban is also a strong blood thinner. Combining them makes your blood much less likely to clot.

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Why this happens

Both medicines affect how your blood clots but in different ways. Apixaban blocks a specific protein (Factor Xa) involved in clotting, while the aspirin in Bisodol stops platelets (blood cells) from sticking together. When used together, their effects add up, significantly increasing the risk of a haemorrhage.

Do not take Bisodol while you are taking apixaban. If you have indigestion, ask your pharmacist or doctor for an alternative that does not contain aspirin or ibuprofen (such as a simple antacid like Gaviscon or Rennie). If you have already taken them together and notice any unusual bruising, black tarry stools, or bleeding that won't stop, seek medical advice immediately.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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