Can I take Ashwagandha and Vitamin B12 together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known clinical interactions between ashwagandha and vitamin B12. It is generally considered safe to take these two supplements together.
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Why this happens
Ashwagandha (Withania somnifera) and Vitamin B12 (cobalamin) use different pathways in the body. Ashwagandha is primarily metabolised by liver enzymes, while Vitamin B12 is absorbed in the small intestine and stored in the liver. They do not compete for absorption or interfere with each other's effects.
What you should do
Back to contentsYou can continue to take both supplements as directed. However, always inform your doctor or pharmacist about all supplements you are taking, especially if you have an underlying thyroid condition or are scheduled for surgery, as ashwagandha can affect thyroid hormone levels and may have a mild sedative effect.
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Important precautions
Back to contentsPregnancy
Do not use ashwagandha during pregnancy as it may have abortifacient effects (it could cause a miscarriage).
Autoimmune diseases (e.g., Lupus, Rheumatoid Arthritis, Multiple Sclerosis)
Ashwagandha can stimulate the immune system, which may worsen the symptoms of autoimmune conditions.
Hyperthyroidism (overactive thyroid)
Ashwagandha can increase thyroid hormone levels. You must avoid it if you have an overactive thyroid, as it may worsen your condition or interfere with thyroid medications.
Scheduled Surgery
Stop taking ashwagandha at least 2 weeks before surgery; it can slow down the central nervous system and may dangerously increase the effect of anaesthesia.
Food and drink warnings
Back to contentsAlcohol
Ashwagandha has sedative properties and may enhance the effects of alcohol. Combining them can lead to excessive drowsiness, impaired coordination, and slowed reaction times. It is best to avoid or strictly limit alcohol while taking this supplement.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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There are no known harmful interactions between black garlic and vitamin C. In fact, they are often taken together because they both have antioxidant properties.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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