Can I take Aspirin and Per together?

Why this happens

Both drugs belong to a group called NSAIDs. They work by blocking enzymes (COX-1 and COX-2) that protect the lining of your stomach. When taken together, this 'double-up' effect leaves the stomach vulnerable to acid damage. Additionally, ibuprofen can physically block aspirin from reaching the part of the blood cells (platelets) it needs to thin the blood.

Avoid taking these two medicines together unless specifically instructed by your doctor. If you need aspirin for heart protection and require a painkiller, paracetamol is usually a safer choice. If you must take both, take the aspirin at least 30 minutes before the ibuprofen, or 8 hours after. Seek medical help immediately if you notice black, tarry stools or vomit that looks like coffee grounds.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.