Can I take Aspirin and Perindopril together?

Why this happens

Perindopril (an ACE inhibitor) works by widening blood vessels and helping the kidneys remove salt and water. Aspirin can block the production of natural substances called prostaglandins, which the body uses to keep blood vessels open and protect the kidneys. By blocking these, aspirin can counteract the blood-pressure-lowering effects of perindopril and reduce blood flow to the kidneys.

If you are taking low-dose aspirin (75mg to 150mg) for heart protection, it is usually fine to take with perindopril, but your doctor should monitor your blood pressure and kidney function regularly. Avoid taking high-dose aspirin (for pain relief) regularly without speaking to your doctor. Ensure you stay well-hydrated and report any signs of kidney issues, such as changes in urination or swelling in your ankles, to your GP.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.