Can I take Atorvastatin and Eplerenone together?

Why this happens

Atorvastatin is a cholesterol-lowering medicine (statin) and eplerenone is a potassium-sparing diuretic (water pill). They are processed by the body using different pathways and do not interfere with how the other works. There are no shared side effects that would cause concern when combined.

You can continue to take both medications as prescribed by your doctor. As with all medications, you should still attend your regular blood tests to monitor your cholesterol levels, kidney function, and potassium levels.

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

High potassium levels (Hyperkalaemia)

Eplerenone can cause dangerously high levels of potassium in your blood. You must avoid using potassium supplements or salt substitutes containing potassium, and your doctor will need to monitor your blood regularly.

Grapefruit juice

Grapefruit juice can increase the level of atorvastatin in your blood, which may increase the risk of side effects like muscle pain or damage. Avoid drinking large amounts (more than 1.2 litres daily), though a small glass is usually safe.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

Salt substitutes (containing potassium)

Eplerenone is a potassium-sparing medicine that can cause your potassium levels to become too high (hyperkalaemia). You should avoid using salt substitutes that contain potassium (such as Lo-Salt) while taking this medicine.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.