Can I take Atorvastatin and Isosorbide mononitrate together?

Why this happens

Atorvastatin works in the liver to lower cholesterol, while isosorbide mononitrate works by relaxing blood vessels to improve blood flow. They are processed by different pathways in the body and do not interfere with each other's effectiveness or safety.

You can safely take these medicines together as prescribed by your doctor. Always ensure you attend your regular blood tests to monitor your cholesterol levels and liver function while taking a statin.

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

Drinking alcohol while taking isosorbide mononitrate can increase the medicine's blood-pressure-lowering effect, making you feel dizzy, lightheaded, or faint. For atorvastatin, regular heavy drinking increases the risk of liver problems.

Erectile dysfunction treatment (PDE5 inhibitors)

Never take isosorbide mononitrate with treatments for erectile dysfunction (such as sildenafil/Viagra). Combining them can cause a dangerous, life-threatening drop in blood pressure.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.