Can I take Atorvastatin and Reishi together?

Why this happens

Both atorvastatin and reishi are processed by the liver. Reishi may interfere with the enzymes (specifically CYP3A4) that break down atorvastatin, potentially leading to higher levels of the medication in your bloodstream. Additionally, both substances can affect liver function markers.

Consult your doctor before combining these two. If you decide to take them together, watch for signs of liver issues (such as yellowing of the eyes/skin or dark urine) or unusual muscle pain, tenderness, or weakness. Your doctor may want to monitor your liver function more closely.

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Bleeding disorders or surgery

Reishi may increase the risk of bleeding. Stop taking it at least two weeks before any scheduled surgery and use with caution if you take blood-thinning medications.

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.