Can I take Atorvastatin and Rybelsus (semaglutide) together?

Why this happens

Atorvastatin is a statin used to lower cholesterol, primarily processed by the liver (CYP3A4 enzyme). Rybelsus is a GLP-1 receptor agonist used for blood sugar control. While Rybelsus slows down how quickly the stomach empties, it has not been shown to significantly change how the body absorbs or processes atorvastatin.

You can safely take these medications together as prescribed by your doctor. However, because Rybelsus can cause nausea or vomiting when you first start it, monitor yourself for any unusual muscle pain or weakness (a rare side effect of atorvastatin), as dehydration from vomiting can sometimes increase the risk of muscle issues. Always follow the specific dosing instructions for Rybelsus, which must be taken on an empty stomach with a small sip of plain water.

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Pancreatitis

Stop using semaglutide and seek immediate medical help if you experience severe, persistent abdominal pain, as this can be a sign of an inflamed pancreas (pancreatitis).

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

Food and Drink (General)

If you are taking the tablet form of semaglutide, you must take it on an empty stomach with a small sip of plain water (no more than 120ml). You must wait at least 30 minutes before eating, drinking anything else, or taking other oral medicines. Eating too soon will significantly reduce how much medicine your body absorbs.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.