Can I take Brufen and Side effects together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Brufen (ibuprofen) is a medication used to treat pain and inflammation; it does not 'interact' with side effects, but rather causes them. Common side effects include stomach ache, indigestion, and nausea. More serious risks include stomach ulcers or kidney issues if used long-term.
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Why this happens
Ibuprofen works by blocking chemicals called prostaglandins. While this reduces pain, these same chemicals normally protect the stomach lining and help the kidneys function. Reducing them can lead to irritation or damage in these areas.
What you should do
Back to contentsAlways take Brufen with food or a glass of milk to protect your stomach. Use the lowest dose for the shortest time possible. If you have asthma, high blood pressure, or kidney problems, speak to a pharmacist or doctor before use.
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Important precautions
Back to contentsAsthma
Do not take this medicine if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.
Stomach ulcers or bleeding
Avoid this medicine if you have ever had a stomach ulcer, perforation, or bleeding. It significantly increases the risk of serious internal bleeding.
Pregnancy (third trimester)
Do not take this medicine if you are more than 20 weeks pregnant. It can cause serious heart and kidney problems in the unborn baby and reduce amniotic fluid levels.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking Brufen can increase the risk of stomach irritation, bleeding, and ulcers. It is best to limit or avoid alcohol, especially if you are taking this medicine long-term.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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