Can I take Codeine linctus and Sertraline together?

Why this happens

Sertraline can block the liver enzyme (CYP2D6) that your body needs to convert codeine into its active form, morphine. This means the codeine may not work as well. Additionally, both drugs affect serotonin levels in the brain, which can lead to an unhealthy buildup.

You should consult your doctor or pharmacist before taking these together. If your doctor confirms it is safe for you, watch out for signs of serotonin syndrome, such as shivering, sweating, a fast heartbeat, agitation, or muscle stiffness. If you feel very drowsy or find the codeine isn't helping your cough, let your doctor know.

Serotonin Syndrome

Taking codeine and sertraline together increases the risk of serotonin syndrome, a potentially life-threatening condition. Seek urgent medical help if you experience agitation, hallucinations, fast heartbeat, or severe muscle stiffness.

Breathing Problems (e.g. Asthma, COPD)

Do not take codeine if you have severe asthma or breathing difficulties, as it can dangerously slow down your breathing.

Addiction and Withdrawal

Codeine is an opioid that can cause addiction and physical dependence even at low doses. Do not use it for longer than 3 days without medical supervision.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.