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Can I take Codeine paracetamol and Ramipril together?

Drug interaction guide

Taking codeine and ramipril together can cause your blood pressure to drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when you stand up quickly. Additionally, both codeine and ramipril can slightly increase potassium levels in your blood, though this is usually only a concern if you have kidney problems. Paracetamol does not have a significant interaction with ramipril.

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Why this happens

Codeine can have a mild sedative and relaxing effect on the blood vessels, which adds to the blood-pressure-lowering effect of ramipril (an ACE inhibitor). Both drugs can also interfere with how the body handles potassium, potentially leading to higher levels.

It is generally safe to take these together, but you should be careful when first starting the combination. Rise slowly from a sitting or lying position to avoid dizziness. If you feel very dizzy or faint, sit back down and contact your doctor. Ensure your doctor knows you are taking both, especially if you have kidney issues.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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