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Can I take Dytor and Sacumada together?

Drug interaction guide

Taking these two medicines together can cause your blood pressure to drop too low (hypotension) and may affect how well your kidneys work. It can also lead to a significant loss of body fluids (dehydration) and changes in the levels of salts (electrolytes) in your blood.

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Why this happens

Dytor (torasemide) is a 'water tablet' (diuretic) that removes excess fluid and salt from your body. Sacumada (sacubitril/valsartan) is a combination medicine used for heart failure that also lowers blood pressure and affects salt balance. When used together, their effects add up, which can lead to excessive fluid loss and a sharp drop in blood pressure.

You must speak to your doctor before taking these together. They may need to adjust your doses or monitor your kidney function and blood pressure more closely, especially when you first start the treatment. If you feel very dizzy, lightheaded, or faint, sit or lie down immediately and contact your healthcare provider.

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Pregnancy

You must not use this medicine if you are pregnant or planning to become pregnant. It can cause serious injury or death to an unborn baby, particularly if used during the second and third trimesters.

Previous reaction to ACE inhibitors (e.g. Ramipril, Lisinopril)

Do not take this medicine if you have ever experienced angioedema (severe swelling of the face, lips, tongue, or throat) while taking an ACE inhibitor. You must also wait at least 36 hours after stopping an ACE inhibitor before starting Sacumada.

Low blood pressure and Kidney function

Taking these together significantly increases the risk of severe dehydration, dangerously low blood pressure, and kidney strain. You must report any signs of dizziness, fainting, or a significant decrease in urination to your doctor immediately.

Alcohol

Drinking alcohol while taking this medicine can cause your blood pressure to drop too low. This may make you feel dizzy, lightheaded, or faint, especially when standing up. It is best to limit or avoid alcohol until you know how the medicine affects you.

Salt substitutes (Potassium-based)

This medicine can increase the levels of potassium in your blood. Many salt substitutes contain potassium instead of sodium. Using these while taking Sacumada can lead to dangerously high potassium levels (hyperkalaemia). Check with your doctor before using salt substitutes.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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