Can I take Gabapentin and Mirtazaphine together?

Why this happens

Both medications act as central nervous system (CNS) depressants. While they work in different ways, their effects on the brain are 'additive'. This means that when taken together, they 'double up' on their sedative effects, making you much more drowsy than if you took either one alone.

Use this combination with caution. If you have just started taking both or have recently increased your dose, avoid driving or operating heavy machinery until you know how the drugs affect you. Seek medical help immediately if you experience extreme lethargy, shallow breathing, or if you are difficult to wake up. Always inform your doctor if you feel the sedation is too strong to manage.

Opioid use or breathing problems

Gabapentin can cause severe, life-threatening breathing difficulties, especially if taken with opioid painkillers or if you have an existing lung condition (like COPD). Seek urgent medical help if breathing becomes slow or shallow.

Mental health disorders

Both medicines can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment. You must inform a family member or carer and contact your doctor immediately if your mood changes or you feel distressed.

Drug dependence

Gabapentin carries a risk of dependence and addiction. Do not stop taking this medicine suddenly, as this can trigger withdrawal symptoms or serious seizures; your dose must be reduced gradually under medical supervision.

Alcohol

You should avoid or strictly limit alcohol while taking these medicines. Both gabapentin and mirtazapine cause drowsiness and dizziness; alcohol significantly increases these effects, which can lead to dangerous levels of sedation, impaired coordination, and breathing difficulties.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.