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Can I take Humulin i for in cartridge and Indapamide together?

Drug interaction guide

Indapamide may make your insulin (Humulin I) less effective, which could lead to higher blood sugar levels than usual. Conversely, taking these together can sometimes increase the risk of your potassium levels becoming too low.

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Why this happens

Indapamide is a 'water pill' (diuretic) that can reduce the body's sensitivity to insulin and interfere with how the pancreas releases it, leading to higher blood glucose. Additionally, both drugs can lower potassium levels in the blood through different processes.

You should monitor your blood sugar levels more frequently when starting or changing the dose of indapamide. If you notice your readings are consistently high, contact your doctor as your insulin dose may need adjusting. You should also have regular blood tests to check your potassium levels.

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Hypoglycaemia (Low Blood Sugar)

This medicine can cause dangerously low blood sugar. You must know how to recognise symptoms (like sweating, shaking, or confusion) and always carry a fast-acting sugar source. Your ability to drive may be affected if your blood sugar is too low.

Sulphonamide Allergy

Do not take this medicine if you have a known severe allergy to sulphonamide-derived medicines (such as certain antibiotics like co-trimoxazole), as you may have a cross-sensitivity reaction.

Low Potassium (Hypokalaemia)

This medicine can significantly lower your potassium levels. You may need regular blood tests, and you should seek medical advice if you experience unusual muscle weakness, cramps, or an irregular heartbeat.

Alcohol

Alcohol can cause your blood sugar levels to drop dangerously low (hypoglycaemia) or sometimes make them too high. It can also mask the warning signs of a 'hypo'. Avoid drinking alcohol on an empty stomach and always monitor your blood sugar levels closely if you choose to drink.

Salt substitutes (Potassium-based)

Indapamide can affect the levels of electrolytes (like potassium) in your blood. While indapamide often lowers potassium, using salt substitutes that contain potassium should only be done after consulting your doctor, as they may monitor your levels regularly.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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