Can I take Iron supplements and Wellbutrin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There is no known direct interaction between iron supplements and Wellbutrin (bupropion). However, both substances can occasionally cause stomach-related side effects like nausea or constipation, which might be more noticeable if taken together.
In this article:
Video picks for Drug interactions
Why this happens
Iron supplements and bupropion are processed by the body through different pathways. Iron is absorbed in the digestive tract and does not interfere with the liver enzymes that break down bupropion. Furthermore, they do not compete for the same receptors in the brain or body.
What you should do
Back to contentsYou can safely take these together. To reduce the risk of an upset stomach, you may wish to take your iron supplement with food (unless your doctor has told you otherwise) and take your Wellbutrin at its usual scheduled time. If you experience significant constipation, ensure you drink plenty of water and speak to a pharmacist.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Calcium and Ciprofloxacin together?
Taking calcium at the same time as ciprofloxacin can significantly reduce the amount of the antibiotic that gets into your bloodstream. This means the medicine may not work properly to clear your infection.

Treatment and medication
Can I take Ibuprofen and Diclofenac together?
Taking ibuprofen and diclofenac together significantly increases your risk of serious side effects, particularly stomach ulcers, internal bleeding, and kidney problems. Because they both belong to the same family of medicines, taking them together is like taking a double dose of the same type of drug.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.