Can I take Shiitake and White button together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There are no known harmful interactions between shiitake mushrooms and white button mushrooms when eaten as part of a normal diet.
In this article:
Why this happens
Both are edible fungi that are processed by the body as food. They do not interfere with each other's absorption or breakdown in the body.
What you should do
Back to contentsIt is safe to consume these mushrooms together. However, if you are taking medicinal shiitake supplements (which are much more concentrated than food), always check with a healthcare professional, especially if you are on blood-thinning medication.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Calcium and Esomeprazole together?
Taking esomeprazole for a long time may reduce how much calcium your body absorbs from your diet or from certain supplements. This can lead to weaker bones and an increased risk of fractures, particularly in the hip, wrist, or spine, if used at high doses for over a year.

Treatment and medication
Can I take Black cohosh and Vitamin C together?
There are no known significant interactions between black cohosh and vitamin C. It is generally considered safe to take these two supplements together.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.